Research Highlights from the Diabetes Obesity and Metabolism Institute (DOMI)
- Dr.Andrew Stewart, MD, the Irene and Dr. Arthur M. Fishberg Professor of Medicine
and Director of Mount Sinai’s Diabetes, Obesity and Metabolism Institute led a
team of scientists who discovered a novel mechanism that regulates the
replication of insulin-producing beta cells in the pancreas. Their findings
provide novel working models describing the control of cell cycle progression
in the human beta cell. These discoveries offer new
insights into possible therapeutic approaches to stimulate the regeneration of
pancreatic beta cells in patients with type 1 and type 2 diabetes. To find out more about this discovery, click here.
- In a
study published in Cell
Metabolism,
Christoph Buettner, MD, PhD, Associate Professor of Medicine, and Neuroscience
and colleagues recently reported that
that impairment in insulin action in the brain may be one of the earliest
defects that occurs in obese patients who eventually develop diabetes. To find out more about this discovery, click here.
- In a
study published in the Journal of
Autoimmunity, Dr. Yaron Tomer (Chief of the Division of Endocrinology,
Diabetes and Bone Disease) and colleagues recently reported that epigenetic
changes, which are changes in the way genes work when they are not mutated,
play a key role in the development of type 1 diabetes. To find out more about this discovery, click here.
