RESEARCH
UPDATE
Update
from the Diabetes
Obesity Metabolism Institute (DOMI)
 |
| Andrew Stewart MD, Director of DOMI |
The Diabetes
Obesity Metabolism Institute (DOMI)is the principal
research arm for diabetes, obesity and metabolism activities at Mount Sinai. It includes
a core of 23 research faculty, who collectively garner $8Million annually in
research support from the National
Institutes of Health (NIH), the Juvenile
Diabetes Research Foundation, the American
Diabetes Association, and other funding
agencies and foundations. Together with the Albert Einstein College of
Medicine/Montefiore Health System, DOMI shares one of 16 Diabetes
Research Center grants from the NIH. In
addition to the 23 primary DOMI faculty members, there are an additional 40-50
affiliated members at Mount Sinai who work in diabetes/obesity related
research. Mount Sinai has a long and proud history of diabetes research, from
the discovery of the first blood tests to measure insulin which led to the 1977
Nobel Prize, to many new "firsts", some examples of which follow. You
can learn much more from our website!
Type
1 Diabetes (T1D):
- Through Carol Levy MD and David Lam MD, in Endocrinology, we have initiated New York City's largest Artificial Pancreas research program.
- Peng Wang PhD, Rupangi Vasavada PhD, Nagesha Kondewgowda PhD and Andrew Stewart MD have discovered the first drugs that are able to induce human beta cells to regenerate.
- Dirk Homann MD, PhD was recruited to spearhead research program in the autoimmunity that underlies T1D.
Type
2 Diabetes (T2D):
- Daniel Donovan MD and Jeanine Albu MD lead a large and growing portfolio of T2D clinical research programs at Mount Sinai Hospital and the new Diabetes Research Center at Mount Sinai-Saint Lukes.
- Donald Scott MD, Christoph Buettner MD, PhD, and Adolfo-Garcia-Ocaña PhD
- Derek LeRoith MD and Emily Gallagher MD comprise a leading a center exploring the link between T2D and cancer risk.
Obesity
- We have the largest bariatric surgery program in New York City, based at Mount Sinai Hospital and Mount Sinai St. Luke's.
- We have outstanding research programs in adipocyte (fat cell) metabolism, led by Susan Fried PhD, Kalypso Karastergiou MD PhD and others.
- These are coupled with internationally renowned obesity genomics programs led by Ruth Loos PhD.
Brain
Control of Metabolism:
- Led by Drs. Christoph Buettner and Sarah Stanley, and in collaboration with theFriedman Brain Institute at Mount Sinai, we have one of the premier centers in the US. Researchers are showing that the brain controls not only appetite, but also metabolic rate in fat tissue, liver and muscle: the main organs that consume calories and generate heat to balance calorie intake from food. Read -more here about the Buettner lab
Artificial
Pancreas (AP) Program Update
Research
continues to proceed in this exciting area! We have competed the initial
testing of the Type Zero AP system and have a collaboration with Rensselaer
Polytechnic Institute studying a novel new system. We anticipate the Type Zero
main study will begin enrolling in the Spring of 2017. The Animas AP system
study is planned to open to enrollment late spring as well. Additional studies
are being finalized and more will opening over the next few months! For those
of you on injections, we have not forgotten about you! Studies are planned for
a support system for people on daily injections to manage their diabetes. If
you have further questions about any AP studies, please
call Selassie Ogyaadu, MD, MPH research coordinator at 212-241-9089.
